BIRC3 anticorps (Internal Region)

N° du produit ABIN569625

Cet anticorps anti-BIRC3 Polyclonal Chèvre (ABIN569625) détecte spécifiquement BIRC3 dans WB et EIA. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour BIRC3 anticorps (Internal Region) (ABIN569625)

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reactivité: Humain, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-BIRC3 anticorps

Épitope: Internal Region

Séquence: C-SVNNLEATSQ P

Specificité: Recognizes BIRC3.

Réactivité croisée (Details): Species reactivity (expected):Human.
Species reactivity (tested):Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_001156.1. Genename: BIRC3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Reported variants represent identical protein: NP_892007.1, NP_001156.1.

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BIRC3

Antigène: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Autre désignation: IAP1 / BIRC3

Sujet: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and -7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.Synonyms: API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing protein 3, C-IAP2, HIAP-1, IAP homolog C, Inhibitor of apoptosis protein 1, MIHC, RING finger protein 49, RNF49, TNFR2-TRAF-signaling complex protein 1, cIAP2

ID gène: 330

NCBI Accession: NP_001156

UniProt: Q13489

Pathways: Apoptose, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades