MMP2 anticorps (AA 424-660)

N° du produit ABIN5699311

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP2 dans WB, IHC, ELISA et IP. Il présente une réactivité envers Humain, Rat, Souris et Poisson zèbre (Danio rerio).

Aperçu rapide pour MMP2 anticorps (AA 424-660) (ABIN5699311)

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivité: Humain, Rat, Souris, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Détail du produit anti-MMP2 anticorps

Épitope: AA 424-660

Fonction: MMP2 antibody

Immunogène:

Immunogen sequence: 424-660aa

Immunogen: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Isotype: IgG

Information d'application

Indications d'application: WB : 1:200-1:2000 IP : 1:200-1:1000 IHC : 1:100-1:400 IF : 1:50-1:500

Commentaires:

MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05238(MMP2 antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MMP2

Antigène: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Autre désignation: MMP2

Sujet:

Synonyms: 72 kDa type IV collagenase|72 kDa gelatinase|Gelatinase A|Matrix metalloproteinase-2 (MMP-2)|TBE-1|PEX|MMP2|CLG4A

Background: This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 72 kDa, 60 kDa

ID gène: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response