DDB1 anticorps

N° du produit ABIN5699738

L’anticorps Lapin Polyclonal anti-DDB1 a été validé pour WB, IHC, ELISA et IP. Il convient pour détecter DDB1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DDB1 anticorps (ABIN5699738)

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Détail du produit anti-DDB1 anticorps

Fonction: DDB1 antibody

Immunogène: damage-specific DNA binding protein 1, 127kDa

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02284(DDB1 antibody) at dilution of 1:500

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1

Sujet:

Synonyms: DNA damage-binding protein 1|DDB p127 subunit|DNA damage-binding protein a (DDBa)|Damage-specific DNA-binding protein 1|HBV X-associated protein 1 (XAP-1)|UV-damaged DNA-binding factor|UV-damaged DNA-binding protein 1 (UV-DDB 1)|XPE-binding factor (XPE-BF)|Xeroderma pigmentosum group E-complementing protein (XPCe)|DDB1|XAP1

Background: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Poids moléculaire: 127 kDa

ID gène: 1642

UniProt: Q16531

Pathways: Réparation de l'ADN