CD44 anticorps (C-Term)

N° du produit ABIN5706818

N° du produit (Fournisseur): 600-401-gt4

L’anticorps anti-CD44 Polyclonal Lapin est utilisé pour la détection de CD44 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour CD44 anticorps (C-Term) (ABIN5706818)

Antigène: CD44

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD44 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CD44 anticorps

Épitope: C-Term

N° du produit (Fournisseur): 600-401-gt4

Fournisseur: Rockland

Fonction: CD44 Antibody

Réactivité croisée (Details): Anti-CD44 Antibody is directed against human CD44 protein.

Attributs du produit: Synonyms: Rabbit anti-CD44 Antibody, CD 44, CD-44 antibody, CDw44, HCAM, homing cell adhesion molecule, lymphocyte homing receptor, LHR, ECM-III, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, HUTCH-1, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Pgp-1, phagocytic glycoprotein-1, Phagocytic glycoprotein 1, PGP1, Phagocytic glycoprotein I, MDU2, MDU3, MIC4

Purification: CD44 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.

Stérilité: Sterile filtered

Immunogène:

Immunogen: Anti-CD44 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the c-terminal region of human CD44.

Immunogen Type: Conjugated Peptide

Isotype: IgG

Information d'application

Indications d'application:

Application Note: Anti-CD44 Antibody has been tested for use in ELISA and Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 81.5 kDa in Western Blots of specific cell lysates and tissues.

Western Blot Dilution: 1.0 μg/mL

ELISA Dilution: 5.0 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur CD44

Antigène: CD44

Autre désignation: CD44

Sujet: Background: CD44 was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). CD44 is a receptor for hyaluronic acid (HA), an integral component of the extracellular matrix. CD44 mediates cell-cell and cell-matrix interactions through its affinity for HA, and can also interact with ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). The multiple protein isoforms are encoded by a single gene by alternative splicing and are further modified by a range of post-translational modifications. CD44 function is controlled by these posttranslational modifications. The major physiological role of CD44 is to maintain organ and tissue structure via cell-cell and cell-matrix adhesion, but certain variant isoforms can also mediate lymphocyte activation and homing, and the presentation of chemical factors and hormones. CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 is a multi-structural and multi-functional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, chemokines, and growth factors to the corresponding receptors, and docking of proteases at the cell membrane, as well as in signaling for cell survival. All these biological properties are essential to the physiological activities of normal cells, but they are also associated with the pathologic activities of cancer cells. CD44, particularly its variants, may be useful as a diagnostic or prognostic marker of malignancy and, in at least some human cancers, it may be a potential target for cancer therapy.

ID gène: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling