FOXP3 anticorps (N-Term)

N° du produit ABIN5707214

Cet anticorps Rat Monoclonal détecte spécifiquement FOXP3 dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour FOXP3 anticorps (N-Term) (ABIN5707214)

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXP3 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: SB168a

Détail du produit anti-FOXP3 anticorps

Épitope: N-Term

Specificité: Mouse Foxp3 (Mr ~57 kDa). Does not cross react with Human Foxp3. T regulatory cells (Originally called T suppressor cells) are a subpopulation of T cells. Their major roles are to suppress excess immune response of other cells and to maintain tolerance of self-antigens. Initially, researchers used CD4 and CD25 (IL-2 receptor) to identify T suppress subpopulation and purified CD4+CD25+ T cells were used for T cells Suppression Assay, however some other activated T cells also express CD25.1,2 The most convincible molecular marker of Treg cells is Forkhead box protein 3 (Foxp3) which is expressed in the nucleus.3 Anti-Foxp3 antibodies are now widely applied to identify the roles of Treg cells in the development of many diseases, such as cancer, autoimmune disease, and organ transplantation.4,5,6 Scientists found that the over-activation of Treg cells may cause cancer cells to escape from immune surveillance 5. Conversely, patients with autoimmune diseases such as psoriasis, systemic lupus erythematous (SLE) have relative dysfunction of Foxp3 positive cells.7,8 Immunologists are trying to induce immune tolerance in organ transplantation using Treg cells.6

Attributs du produit: Rat Anti-Mouse Foxp3-UNLB

Immunogène: N-terminal recombinant Mouse Foxp3

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: Flow cytometry
• Working Dilutions: Flow Cytometry: FITC conjugate < 1.0 g/106 cells AF647 conjugate < 0.2 g/106 cells

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.1 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur FOXP3

Antigène: FOXP3 (Forkhead Box P3 (FOXP3))

Autre désignation: Foxp3

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation