Recombinant CLIP anticorps (AA 25-39)

N° du produit ABIN5707527

L’anticorps anti-CLIP Monoclonal Lapin est utilisé pour la détection de CLIP dans des échantillons de Humain, Rat et Souris. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant CLIP anticorps (AA 25-39) (ABIN5707527)

Antigène: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CLIP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CLIP-2040R

Détail du produit anti-CLIP anticorps

Épitope: AA 25-39

Fonction: Recombinant ACTH Antibody / CLIP (azide and preservative free)

Séquence: NGAEDESAEA FPLEF

Purification: Protein A affinity chromatography

Immunogène: Amino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: The optimal dilution of the recombinant ACTH antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CLIP

Antigène: CLIP (Corticotropin-Like Intermediate Peptide (CLIP))

Autre désignation: ACTH / CLIP

Sujet: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 17-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

UniProt: P01189