Integrin beta 3 anticorps

N° du produit ABIN5707545

L’anticorps Lapin Monoclonal anti-Integrin beta 3 a été validé pour IHC (p). Il convient pour détecter Integrin beta 3 dans des échantillons de Humain.

Aperçu rapide pour Integrin beta 3 anticorps (ABIN5707545)

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ITGB3-2166R

Détail du produit anti-Integrin beta 3 anticorps

Purification: Purified

Pureté: Protein A affinity

Immunogène: Human recombinant protein was used as the immunogen for the recombinant Integrin beta 3 antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Titration of the recombinant Integrin beta 3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Integrin beta 3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: Integrin beta 3 / ITGB3 / CD61

Sujet: Reacts with human Integrin beta 3, also called CD61. It associates with the α,V-chain (CD51) to form vitronectin receptor, or with the α,IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex