KRT15 anticorps

N° du produit ABIN5707765

Détail du produit anti-KRT15 anticorps

Antigène: KRT15 (Keratin 15 (KRT15))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp KRT15 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the recombinant Cytokeratin 15 antibody.

Clone: KRT15-2103R

Isotype: IgG kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Cytokeratin 15 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Cytokeratin 15 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur KRT15

Antigène: KRT15 (Keratin 15 (KRT15))

Autre désignation: KRT15 / Cytokeratin 15 (KRT15 Produits)

Synonymes: anticorps xlk2, anticorps CK15, anticorps K15, anticorps K1CO, anticorps AI528832, anticorps Krt1-15, anticorps Ka15, anticorps wu:fa91c06, anticorps wu:fa95d04, anticorps zgc:55334, anticorps keratin 15, type I L homeolog, anticorps keratin 15, type I, anticorps keratin 15, anticorps krt15.L, anticorps krt15, anticorps KRT15, anticorps Krt15

Sujet: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.