beta Catenin anticorps

N° du produit ABIN5707937

Cet anticorps Lapin Monoclonal détecte spécifiquement beta Catenin dans IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour beta Catenin anticorps (ABIN5707937)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTNNB1-2030R

Détail du produit anti-beta Catenin anticorps

Purification: Purified

Pureté: Protein A affinity chromatography

Immunogène: Human protein was used as the immunogen for the recombinant b-Catenin antibody.

Isotype: IgG kappa

Information d'application

Indications d'application: Titration of the recombinant b-Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL,Prediluted IHC only format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant b-Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: Beta Catenin

Sujet: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]

Pathways: Peptide Hormone Metabolism