Connexin 31 anticorps (pSer368)

N° du produit ABIN576289

Cet anticorps Lapin Monoclonal détecte spécifiquement Connexin 31 dans WB. Il présente une réactivité envers Rat.

Aperçu rapide pour Connexin 31 anticorps (pSer368) (ABIN576289)

Antigène: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Connexin 31 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Connexin 31 anticorps

Épitope: pSer368

Specificité: Recognizes the ~43 kD Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighboring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. A decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C. A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumors and peritumoural reactive astrocytes.

Purification: Purified

Immunogène: Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 ( pSer368 ).

Type of Immunogen: Synthetic phospho-peptide

Isotype: IgG

Information d'application

Indications d'application: Approved: WB (1:1000)

Usage: Western Blot: LS-C43142 detects a band of approximately 43kD in rat hippocampus cell lysates.

Commentaires:

Target Species of Antibody: Rat

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 10 mM HEPES,  pH 7.5, 0.09 % sodium azide, 0.01 % BSA, 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur Connexin 31

Antigène: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Autre désignation: GJB3 / CX31 / Connexin 31

Sujet: Name/Gene ID: GJB3
Subfamily: Connexin
Family: Ion Channel

Synonyms: GJB3, Connexin 31, Connexin-31, CX31, DFNA2, Erythrokeratodermia variabilis, Gap junction beta-3 protein, DFNA2B, EKV, Gap junction protein beta 3

ID gène: 2707

Pathways: Sensory Perception of Sound