LSD1 anticorps
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- Antigène Voir toutes LSD1 (KDM1A) Anticorps
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
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Reactivité
- Humain, Mammifères
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp LSD1 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Marque
- AbX™
- Attributs du produit
- Reacts with mammalian Lysine Specific Demethylase 1
- Purification
- Purified
- Immunogène
- Full length recombinant Lysine Specific Demethylase 1
- Top Product
- Discover our top product KDM1A Anticorps primaire
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- Indications d'application
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Western blotting and Immunoprecipitation
Western blotting, 1:50-1:200 AbX™ Anti-LSD1 Rabbit pAb
Detection of LSD1 in nuclear extract of 20 μg of HeLa cells probed with A003-100UL at a 1:200 dilution. MW of LSD1 is 110 kDa. - Commentaires
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Reacts with mammalian Lysine Specific Demethylase 1 Supplied as a PBS solution Applications include Western blotting and Immunoprecipitation
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Phosphate Buffered Saline at pH 7.2 containing 0.1 % Tween 20 and 0.09 % Kathon preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Stock
- 4 °C
- Stockage commentaire
- Short Term: 4°C. Extended: Aliquot and freeze at -20°C
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- Antigène
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
- Autre désignation
- Lysine Specific Demethylase 1 (LSD1) (KDM1A Produits)
- Synonymes
- anticorps AOF2, anticorps BHC110, anticorps KDM1, anticorps LSD1, anticorps 1810043O07Rik, anticorps AA408884, anticorps Aof2, anticorps D4Ertd478e, anticorps Kdm1, anticorps Lsd1, anticorps mKIAA0601, anticorps DKFZp459N2450, anticorps RGD1562975, anticorps aof2, anticorps kdm1, anticorps wu:fb82e06, anticorps wu:fc51a02, anticorps wu:fj36a05, anticorps wu:fj66b06, anticorps KDM1A, anticorps lsd1, anticorps xLSD1, anticorps AtLSD1, anticorps F9F13.30, anticorps F9F13_30, anticorps LESION SIMULATING DISEASE, anticorps LESION SIMULATING DISEASE 1, anticorps lysine demethylase 1A, anticorps lysine (K)-specific demethylase 1A, anticorps lysine (K)-specific demethylase 1a, anticorps LSD1 zinc finger family protein, anticorps KDM1A, anticorps Kdm1a, anticorps kdm1a, anticorps LSD1
- Sujet
- There are two known classes of histone demethylases (HDM), differing in their reaction chemistry, coenzyme use and reaction products. Flavin-dependent HDMs act only on mono- and dimethylated lysines and produce hydrogen peroxide, whereas the Jumonji-containing HDMs are iron-dependent enzymes that can act on mono-, di- and trimethylated lysine side chains, and also on methylated Arginine residues. Both classes also produce formaldehyde as a product of the demethylation reaction. LSD1 (Lysine-specific demethylase 1) is a flavin- dependent amine oxidase and was identified as a subunit of different complexes and has been shown to be involved in transcriptional repression of genes through the demethylation of monomethyl Lys4 and dimethyl Lys4 Histone H3. LSD1 is also involved in transcriptional activation through the demethylation of monomethyl Lys9 and dimethyl Lys9 Histone H3. It is also able to demethylate both mono- and dimethyl Lys370 in the regulatory domain of the tumor suppressor p53.
- Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg
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