GRIA2 anticorps (Ser880)

N° du produit ABIN5956617

L’anticorps Lapin Polyclonal anti-GRIA2 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter GRIA2 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour GRIA2 anticorps (Ser880) (ABIN5956617)

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GRIA2 anticorps

Épitope: Ser880

Specificité: AMPA 2,AMPA selective glutamate receptor 2,AMPA-selective glutamate receptor 2,AMPA2,GluA2,GLUR 2,GLUR B,GluR K2,GluR-2,GluR-B,GluR-K2,GLUR2,GLURB,Glutamate receptor 2,Glutamate receptor ionotropic AMPA 2,Glutamate receptor ionotropic,Gria2,GRIA2,HBGR2

Purification: Affinity purification

Immunogène: Synthesized peptide derived from human GluR-2 around the non-phosphorylation site of Ser880.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GRIA2

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Autre désignation: GluR-2

Sujet: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

Poids moléculaire: 99kDa

ID gène: 2891

UniProt: P42262

Pathways: Signalisation PI3K-Akt