CTLA4 anticorps

N° du produit ABIN610400

Détail du produit anti-CTLA4 anticorps

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Specificité: CTLA-4 expressed on activated T cells.

Purification: Protein A purified

Immunogène: Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein

Clone: ANC152-2-8H5

Isotype: IgG1 kappa

Information d'application

Indications d'application: Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 0.5 mg/mL Gentamicin sulfate

Agent conservateur: Gentamicin sulfate

Précaution d'utilisation: This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 4°C. Do not freeze.

Références pour anticorps anti-CTLA4 (ABIN610400)

Chang, Xing, Pan, Algeciras-Schimnich, Barnhart, Yaish-Ohad, Peter, Yang: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." dans: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, (2002) (PubMed).

MacFarlane, Harper, Snowden, Dyer, Barnett, Pringle, Cohen: "Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia." dans: Oncogene, Vol. 21, Issue 44, pp. 6809-18, (2002) (PubMed).

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA4 / CD152 (CTLA4 Produits)

Synonymes: anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4

Sujet: Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform

ID gène: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints