CTLA4 anticorps

N° du produit ABIN610404

Cet anticorps anti-CTLA4 est un anticorps Souris Monoclonal détectant CTLA4 dans FACS, ELISA et Func. Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour CTLA4 anticorps (ABIN610404)

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Fragment: Fab fragment

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTLA4 est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Functional Studies (Func)

Clone: ANC152-2-8H5

Détail du produit anti-CTLA4 anticorps

Specificité: CTLA-4 expressed on activated T cells.

Purification: Gel filtration

Stérilité: 0.1 μm filtered

Immunogène: Stimulated human PBL’,s and human CD152 Ig fusion protein.

Type of Immunogen: Fusion protein

Isotype: IgG1 kappa

Information d'application

Indications d'application: Approved: ELISA, Flo, Func

Usage: Function: ANC152.2 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory Cells in Vitro. ANC152.2 can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride. Product was 0.1 μm filtered, vialed under aseptic conditions. No preservative added

Agent conservateur: Without preservative

Conseil sur la manipulation: Do not freeze. Open under aseptic conditions.

Stock: 4 °C

Stockage commentaire: Store at 4°C. Do not freeze. Open under aseptic conditions.

Références pour anticorps anti-CTLA4 (ABIN610404)

Zundel, Swiersz, Giaccia: "Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide." dans: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1507-14, (2000) (PubMed).

Chitaev, Troyanovsky: "Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation." dans: The Journal of cell biology, Vol. 142, Issue 3, pp. 837-46, (1998) (PubMed).

Behrens, Vakaet, Friis, Winterhager, Van Roy, Mareel, Birchmeier et al.: "Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC ..." dans: The Journal of cell biology, Vol. 120, Issue 3, pp. 757-66, (1993) (PubMed).

Détails sur CTLA4

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA4 / CD152

Sujet: Name/Gene ID: CTLA4

Synonyms: CTLA4, CD152, CELIAC3, CD152 antigen, CTLA-4, Celiac disease 3, IDDM12, GRD4, GSE, CD152 isoform

ID gène: 1493

UniProt: P16410

Pathways: Cancer Immune Checkpoints