FGD4 anticorps (AA 99-198)

N° du produit ABIN6140588

Détail du produit anti-FGD4 anticorps

Antigène: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Épitope: AA 99-198

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGD4 est non-conjugé

Application: Western Blotting (WB)

Séquence: QMECEEEKAA TLSSDTSIQA SEPLLDTHIV NGERDETATA PASPTTDSCD GNASDSSYRT PGIGPVLPLE ERGAETETKV QERENGESPL ELEQLDQHHE

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human FGD4 (NP_640334.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur FGD4

Antigène: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Autre désignation: FGD4 (FGD4 Produits)

Synonymes: anticorps CMT4H, anticorps FRABP, anticorps ZFYVE6, anticorps 9030023J02Rik, anticorps 9330209B17Rik, anticorps Frabp, anticorps FYVE, RhoGEF and PH domain containing 4, anticorps FGD4, anticorps Fgd4

Sujet: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.,FGD4,CMT4H,FRABP,ZFYVE6,FYVE,FGD4

Poids moléculaire: 20 kDa/32 kDa/86 kDa

ID gène: 121512

UniProt: Q96M96

Pathways: Neurotrophin Signaling Pathway