GP1BB anticorps (AA 27-147)

N° du produit ABIN6141287

Cet anticorps Lapin Polyclonal détecte spécifiquement GP1BB dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour GP1BB anticorps (AA 27-147) (ABIN6141287)

Antigène: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GP1BB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GP1BB anticorps

Épitope: AA 27-147

Séquence: PAPCSCAGTL VDCGRRGLTW ASLPTAFPVD TTELVLTGNN LTALPPGLLD ALPALRTAHL GANPWRCDCR LVPLRAWLAG RPERAPYRDL RCVAPPALRG RLLPYLAEDE LRAACAPGPL C

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 27-147 of human GP1BB (NP_000398.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GP1BB

Antigène: GP1BB (Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB))

Autre désignation: GP1BB

Sujet: Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.,GP1BB,BDPLT1,BS,CD42C,GPIBB,GPIbbeta,Immunology & Inflammation,CD markers,GP1BB

Poids moléculaire: 21 kDa/43 kDa

ID gène: 2812

UniProt: P13224