HSD11B2 anticorps (AA 266-405)

N° du produit ABIN6142000

Cet anticorps Lapin Polyclonal détecte spécifiquement HSD11B2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour HSD11B2 anticorps (AA 266-405) (ABIN6142000)

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HSD11B2 anticorps

Épitope: AA 266-405

Séquence: KTESVRNVGQ WEKRKQLLLA NLPQELLQAY GKDYIEHLHG QFLHSLRLAM SDLTPVVDAI TDALLAARPR RRYYPGQGLG LMYFIHYYLP EGLRRRFLQA FFISHCLPRA LQPGQPGTTP PQDAAQDPNL SPGPSPAVAR

Réactivité croisée: Humain, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 266-405 of human HSD11B2 (NP_000187.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HSD11B2

Antigène: HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))

Autre désignation: HSD11B2

Sujet: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.,HSD11B2,AME,AME1,HSD11K,HSD2,SDR9C3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Cardiovascular,Hypoxia,Heart,Cardiovascular diseases,Hypertension,Heart disease,HSD11B2

Poids moléculaire: 44 kDa

ID gène: 3291

UniProt: P80365

Pathways: Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones