PIKFYVE anticorps (AA 172-451)

N° du produit ABIN6145651

L’anticorps Lapin Polyclonal anti-PIKFYVE a été validé pour WB. Il convient pour détecter PIKFYVE dans des échantillons de Humain.

Aperçu rapide pour PIKFYVE anticorps (AA 172-451) (ABIN6145651)

Antigène: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIKFYVE est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PIKFYVE anticorps

Épitope: AA 172-451

Séquence: DLAWQSLIHP DSSNTPLSTR LVSVQEDAGK SPARNRSASI TNLSLDRSGS PMVPSYETSV SPQANRTYVR TETTEDERKI LLDSVQLKDL WKKICHHSSG MEFQDHRYWL RTHPNCIVGK ELVNWLIRNG HIATRAQAIA IGQAMVDGRW LDCVSHHDQL FRDEYALYRP LQSTEFSETP SPDSDSVNSV EGHSEPSWFK DIKFDDSDTE QIAEEGDDNL ANSASPSKRT SVSSFQSTVD SDSAASISLN VELDNVNFHI KKPSKYPHVP PHPADQKGRR

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 172-451 of human PIKFYVE (NP_689884.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PIKFYVE

Antigène: PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Autre désignation: PIKFYVE

Sujet: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve, also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD), an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,PIKFYVE,CFD,FAB1,HEL37,PIP5K,PIP5K3,ZFYVE29,Cancer,Signal Transduction,Kinase,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Endocrine & Metabolism,Lipid Metabolism,PIKFYVE

Poids moléculaire: 50 kDa/51 kDa/61 kDa/237 kDa

ID gène: 200576

UniProt: Q9Y2I7

Pathways: Inositol Metabolic Process