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PSME4 anticorps (AA 1634-1843)

PSME4 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6146359
  • Antigène Voir toutes PSME4 Anticorps
    PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
    Épitope
    • 4
    • 1
    • 1
    • 1
    AA 1634-1843
    Reactivité
    • 8
    • 2
    • 2
    Humain
    Hôte
    • 8
    Lapin
    Clonalité
    • 8
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    Cet anticorp PSME4 est non-conjugé
    Application
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    LYPHQVPLVL QVLKQTARSS SWHARYTVLT YLQTMVFYNL FIFLNNEDAV KDIRWLVISL LEDEQLEVRE MAATTLSGLL QCNFLTMDSP MQIHFEQLCK TKLPKKRKRD PGSVGDTIPS AELVKRHAGV LGLGACVLSS PYDVPTWMPQ LLMNLSAHLN DPQPIEMTVK KTLSNFRRTH HDNWQEHKQQ FTDDQLLVLT DLLVSPCYYA
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1634-1843 of human PSME4 (NP_055429.2).
    Isotype
    IgG
    Top Product
    Discover our top product PSME4 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
    Autre désignation
    PSME4 (PSME4 Produits)
    Synonymes
    anticorps proteasome activating protein 200, anticorps Afu4g11290, anticorps An04g05320, anticorps AO090003001091, anticorps PA200, anticorps AA409398, anticorps AU041366, anticorps TEMO, anticorps mKIAA0077, anticorps proteasome activator subunit 4, anticorps proteasome activating protein 200, anticorps proteasome (prosome, macropain) activator subunit 4, anticorps PSME4, anticorps Psme4, anticorps PA200, anticorps AFUA_4G11290, anticorps ANI_1_888184, anticorps AOR_1_1944154, anticorps TERG_07227, anticorps psme4
    Sujet
    Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.,PSME4,PA200,Cell Biology & Developmental Biology,Ubiquitin,PSME4
    Poids moléculaire
    24 kDa/113 kDa/139 kDa/211 kDa
    ID gène
    23198
    UniProt
    Q14997
    Pathways
    DNA Replication, Synthesis of DNA
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