PSME4 anticorps

N° du produit ABIN7117899

Cet anticorps anti-PSME4 Polyclonal Lapin (ABIN7117899) détecte spécifiquement PSME4 dans WB, ELISA, IHC, IF et IP. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PSME4 anticorps (ABIN7117899)

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-PSME4 anticorps

Fonction: PSME4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: proteasome(prosome, macropain) activator subunit 4

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:1000 , IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PSME4

Antigène: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Autre désignation: PSME4

Sujet:

Synonyms: Proteasome activator complex subunit 4|Proteasome activator PA200|PSME4|KIAA0077

Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP-and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like(BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Poids moléculaire: 140 kDa

ID gène: 23198

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA