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SMN2 anticorps (AA 1-197)

SMN2 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6148135
  • Antigène Voir toutes SMN2 Anticorps
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Épitope
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-197
    Reactivité
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 6
    • 5
    Lapin
    Clonalité
    • 8
    • 3
    Polyclonal
    Conjugué
    • 11
    Cet anticorp SMN2 est non-conjugé
    Application
    • 9
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS DNIKPKSAPW NSFLPPP
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human SMN2 (NP_059107.1).
    Isotype
    IgG
    Top Product
    Discover our top product SMN2 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Commentaires

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    SMN2 (Survival of Motor Neuron 2, Centromeric (SMN2))
    Autre désignation
    SMN2 (SMN2 Produits)
    Synonymes
    anticorps BCD541, anticorps C-BCD541, anticorps GEMIN1, anticorps SMNC, anticorps TDRD16B, anticorps bcd541, anticorps c-bcd541, anticorps gemin-1, anticorps smn2, anticorps smnc, anticorps survival of motor neuron 2, centromeric, anticorps survival of motor neuron 2, centromeric L homeolog, anticorps SMN2, anticorps smn2.L
    Sujet
    This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.,SMN2,BCD541,C-BCD541,GEMIN1,SMNC,TDRD16B,SMN2
    Poids moléculaire
    27 kDa/28 kDa/30 kDa/31 kDa
    ID gène
    6607
    UniProt
    Q16637
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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