beta Amyloid anticorps (C-Term) (Biotin)

N° du produit ABIN614816

L’anticorps Souris Monoclonal anti-beta Amyloid a été validé pour EIA et ELISA (Detection). Il convient pour détecter beta Amyloid dans des échantillons de Humain.

Aperçu rapide pour beta Amyloid anticorps (C-Term) (Biotin) (ABIN614816)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est conjugé à/à la Biotin

Application: Enzyme Immunoassay (EIA), ELISA (Detection)

Clone: CV9 7B10

Détail du produit anti-beta Amyloid anticorps (Biotin)

Épitope: C-Term

Séquence: GLMVGGVV

Specificité: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ40 and full length Aβ40. The antibody does not cross react with amyloid beta peptide 42 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein G affinity chromatohraphy

Immunogène: C-terminal amino acid sequence of human beta amyloid peptide 40, conjugated with KLH

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % gelatin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

ID gène: 351

Pathways: Inflammasome