beta Amyloid anticorps (C-Term) (Biotin)

N° du produit ABIN614820

Cet anticorps anti-beta Amyloid Monoclonal Souris conjugué à Biotin (ABIN614820) détecte spécifiquement beta Amyloid dans EIA et ELISA (Detection). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour beta Amyloid anticorps (C-Term) (Biotin) (ABIN614820)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est conjugé à/à la Biotin

Application: Enzyme Immunoassay (EIA), ELISA (Detection)

Détail du produit anti-beta Amyloid anticorps (Biotin)

Épitope: C-Term

Séquence: MVGGVVIA

Specificité: This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ42 and full length Aβ42. The antibody does not cross react with amyloid beta peptide 40 in dot blotting and ELISA. Cross-reactivity to amyloid beta peptide 43 is less than 1 % in ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human and other primates, Mouse, Rat.

Purification: Protein G affinity chromatography

Immunogène: C-terminal of human beta amyloid peptide 42, conjugated with KLH

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M PBS, pH 7.0 ± 0.1, 0.1 % Proclin-300, 1 % Gelatin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

ID gène: 351

Pathways: Inflammasome