UBL4A anticorps (AA 1-157)

N° du produit ABIN6149851

Cet anticorps Lapin Polyclonal détecte spécifiquement UBL4A dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour UBL4A anticorps (AA 1-157) (ABIN6149851)

Antigène: UBL4A (Ubiquitin-Like 4A (UBL4A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBL4A est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-UBL4A anticorps

Épitope: AA 1-157

Séquence: MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL ADGKRLSDYS IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS KVLARHFSAA DASRVLEQLQ RDYERSLSRL TLDDIERLAS RFLHPEVTET MEKGFSK

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-157 of human UBL4A (NP_055050.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:1000,IP,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur UBL4A

Antigène: UBL4A (Ubiquitin-Like 4A (UBL4A))

Autre désignation: UBL4A

Sujet: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD, a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.,UBL4A,DX254E,DXS254E,G6PD,GDX,GET5,MDY2,TMA24,UBL4,Cell Biology & Developmental Biology,Ubiquitin,UBL4A

Poids moléculaire: 17 kDa

ID gène: 8266

UniProt: P11441

Pathways: Ubiquitin Proteasome Pathway