ULK1 anticorps (AA 400-499)

N° du produit ABIN6149921

Cet anticorps Lapin Polyclonal détecte spécifiquement ULK1 dans WB et IF. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour ULK1 anticorps (AA 400-499) (ABIN6149921)

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-ULK1 anticorps

Épitope: AA 400-499

Séquence: RTPSPSPPCS SSPSPSGRAG PFSSSRCGAS VPIPVPTQVQ NYQRIERNLQ SPTQFQTPRS SAIRRSGSTS PLGFARASPS PPAHAEHGGV LARKMSLGGG

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 400-499 of human ULK1 (NP_003556.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IF,1:10 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-ULK1 (ABIN6149921)

Xu, Zhang, Liu, Wu, Qin, Huang: "Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells." dans: Oncology letters, Vol. 15, Issue 6, pp. 9719-9724, (2018) (PubMed).

Détails sur ULK1

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Autre désignation: ULk1

Sujet: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.,ULK1,ATG1,ATG1A,UNC51,Unc51.1,hATG1,ULk1,Signal Transduction,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Mitochondrial metabolism,Mitophagy fission and fusion,Neuroscience,Cardiovascular,Heart,Regulator of mTOR complex function,Regulators,ULk1

Poids moléculaire: 112 kDa

ID gène: 8408

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy