USP13 anticorps (AA 90-200)

N° du produit ABIN6149996

Cet anticorps Lapin Polyclonal détecte spécifiquement USP13 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour USP13 anticorps (AA 90-200) (ABIN6149996)

Antigène: USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-USP13 anticorps

Épitope: AA 90-200

Séquence: MHLKRHVREK VRGASGGALP KRRNSKIFLD LDTDDDLNSD DYEYEDEAKL VIFPDHYEIA LPNIEELPAL VTIACDAVLS SKSPYRKQDP DTWENELPVS KYANNLTQLD N

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 90-200 of human USP13 (NP_003931.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:2000,IHC,1:50 - 1:200

Commentaires:

HIGH QUALITY

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur USP13

Antigène: USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))

Autre désignation: USP13

Sujet: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD. Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data.,USP13,ISOT3,IsoT-3,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP13

Poids moléculaire: 90 kDa/97 kDa

ID gène: 8975

UniProt: Q92995

Pathways: SARS-CoV-2 Protein Interactome