IGFBPI anticorps

N° du produit ABIN615635

Détail du produit anti-IGFBPI anticorps

Antigène: IGFBPI (Insulin-Like Growth Factor Binding Protein 1 (IGFBPI))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IGFBPI est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: Recognizes Human IGF-BP1

Purification: Affinity Chromatography employing an immobilized Human IGF-BP1

Immunogène: Highly pure (>98%) recombinant Human IGF-BP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2 without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Détails sur IGFBPI

Antigène: IGFBPI (Insulin-Like Growth Factor Binding Protein 1 (IGFBPI))

Autre désignation: IGFBP1 (IGFBPI Produits)

Synonymes: anticorps cb656, anticorps igfbp1, anticorps IGFBP-1, anticorps MGC68538, anticorps afbp, anticorps ibp1, anticorps pp12, anticorps igf-bp25, anticorps higfbp-1, anticorps IGFBP1, anticorps LOC100223208, anticorps LOC100305121, anticorps AFBP, anticorps IBP1, anticorps IGF-BP25, anticorps PP12, anticorps hIGFBP-1, anticorps IGFBA, anticorps insulin like growth factor binding protein 1, anticorps insulin-like growth factor binding protein 1a, anticorps insulin like growth factor binding protein 1 S homeolog, anticorps insulin like growth factor binding protein 1 L homeolog, anticorps insulin-like growth factor binding protein 1, anticorps IGFBP1, anticorps igfbp1a, anticorps igfbp1.S, anticorps igfbp1.L, anticorps igfbp1, anticorps LOC100305121, anticorps Igfbp1

Sujet: Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR).Synonyms: IBP-1, IBP1, IGF-binding protein 1, IGFBP-1, Insulin-like growth factor-binding protein 1, PP12, Placental protein 12

ID gène: 3484

NCBI Accession: NP_000587

UniProt: P08833

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Growth Factor Binding