CARD11 anticorps

N° du produit ABIN615803

Détail du produit anti-CARD11 anticorps

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody reacts to Caspase Recruitment Domain Family, Member 11 (CARD11). Predicted cross-reactivity based on amino acid sequence homology: mouse (96 %), bovine (98 %).

Purification: Immunoaffinity Chromatography

Immunogène: CARD11 antibody was raised against recombinant protein Genename: CARD11

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1,02 mg/mL

Buffer: 0.1 M Tris-glycine, pH 7.0 containing 10 % Glycerol as stabilizer and 0.01 % Thimerosal as preservative

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur CARD11

Antigène: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Autre désignation: CARD11 / CARMA1 (CARD11 Produits)

Synonymes: anticorps BENTA, anticorps BIMP3, anticorps CARMA1, anticorps PPBL, anticorps 0610008L17Rik, anticorps 2410011D02Rik, anticorps CARD11, anticorps LOC100232755, anticorps caspase recruitment domain family member 11, anticorps caspase recruitment domain family, member 11, anticorps caspase recruitment domain-containing protein 11, anticorps CARD11, anticorps Card11, anticorps LOC100550812, anticorps card11

Sujet: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11

ID gène: 84433

NCBI Accession: NP_115791

UniProt: Q9BXL7

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, BCR Signaling