HLA-B anticorps (CF®640R)

N° du produit ABIN6165237

Cet anticorps Souris Monoclonal détecte spécifiquement HLA-B dans FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HLA-B anticorps (CF®640R) (ABIN6165237)

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-B est conjugé à/à la CF®640R

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: JOAN-1

Détail du produit anti-HLA-B anticorps (CF®640R)

Fonction: Mouse Monoclonal anti-HLA-B (JOAN-1), CF640R Conjugate

Attributs du produit: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Normal human peripheral blood lymphocytes

Isotype: IgG3 kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

Human peripheral blood lymphocytes, tonsil or lymph node

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur HLA-B

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Autre désignation: HLA-B

Sujet: HLA-B, HLAB, MHC Class I HLA heavy chain, Leukocyte antigen class I-B

Poids moléculaire: 45 kDa

ID gène: 3106, 77961

UniProt: P03989

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response