Fc gamma RII (CD32) anticorps (Biotin)

N° du produit ABIN6184853

Détail du produit

Antigène: Fc gamma RII (CD32)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Biotin

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Fonction: Mouse Monoclonal anti-CD32 (7.3), Biotin Conjugate

Attributs du produit: This MAb reacts with a CD32 (FcgRII) epitope (cluster-4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (Fc?RII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: K562 and FcgRII L cells

Clone: 7-3

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescence 0.5-1 μg/mL

• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

K-562 cells. Lymph node, tonsil and placenta.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détail du antigène

Antigène: Fc gamma RII (CD32)

Autre désignation: CD32 (CD32 Produits)

Synonymes: anticorps CD32, anticorps CD32B, anticorps FCG2, anticorps FCGR2, anticorps IGFR2, anticorps FCGR2B, anticorps AI528646, anticorps F630109E10Rik, anticorps Fc[g]RII, anticorps FcgRII, anticorps Fcgr2, anticorps Fcgr2a, anticorps Fcr-2, anticorps Fcr-3, anticorps Ly-17, anticorps Ly-m20, anticorps LyM-1, anticorps Lym-1, anticorps FCRII, anticorps FcRII, anticorps Fc fragment of IgG receptor IIb, anticorps Fc receptor, IgG, low affinity IIb, anticorps FCGR2B, anticorps Fcgr2b

Poids moléculaire: 40 kDa

ID gène: 2212, 352642

UniProt: P12318