IRF3 anticorps (pSer385)

N° du produit ABIN6240986

Cet anticorps Lapin Polyclonal détecte spécifiquement IRF3 dans WB, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IRF3 anticorps (pSer385) (ABIN6240986)

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRF3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-IRF3 anticorps

Épitope: pSer385

Immunogène: synthetic peptide

Information d'application

Indications d'application: IF: 1:100. WB: 1:1000. IHC: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détails sur IRF3

Antigène: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Autre désignation: IRF-3

Sujet: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

UniProt: Q14653

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades