NEIL3 anticorps

N° du produit ABIN6241838

Cet anticorps Lapin Polyclonal détecte spécifiquement NEIL3 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NEIL3 anticorps (ABIN6241838)

Antigène: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEIL3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NEIL3 anticorps

Immunogène: synthetic peptide

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: 4 °C,-20 °C

Détails sur NEIL3

Antigène: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Autre désignation: NEIL3

Sujet: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

UniProt: Q8TAT5

Pathways: Réparation de l'ADN