ECT2 anticorps (AA 200-460)

N° du produit ABIN6242298

L’anticorps Souris Monoclonal anti-ECT2 a été validé pour WB. Il convient pour détecter ECT2 dans des échantillons de Humain.

Aperçu rapide pour ECT2 anticorps (AA 200-460) (ABIN6242298)

Antigène: ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ECT2 est non-conjugé

Application: Western Blotting (WB)

Clone: 1691CT516-3-3

Détail du produit anti-ECT2 anticorps

Épitope: AA 200-460

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This ECT2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 200-460 amino acids from human ECT2.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur ECT2

Antigène: ECT2 (Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))

Autre désignation: ECT2

Sujet: Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly, regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity, participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB)- induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.

Poids moléculaire: 103505

UniProt: Q9H8V3

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization