SETD2 anticorps (N-Term)

N° du produit ABIN6242388

Il existe 1 publication pour ce produit. L’anticorps anti-SETD2 Polyclonal Lapin est utilisé pour la détection de SETD2 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour SETD2 anticorps (N-Term) (ABIN6242388)

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETD2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2780

Détail du produit anti-SETD2 anticorps

Épitope: AA 21-50, N-Term

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SETD2 (ABIN6242388)

Müller, Rieder, Karpova, John, Trajanoski, McNally: "Organization of chromatin and histone modifications at a transcription site." dans: The Journal of cell biology, Vol. 177, Issue 6, pp. 957-67, (2007) (PubMed).

Détails sur SETD2

Antigène: SETD2 (SET Domain Containing 2 (SETD2))

Autre désignation: SET2

Sujet: SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.

Poids moléculaire: 287597

NCBI Accession: NP_054878

UniProt: Q9BYW2

Pathways: Tube Formation