IL1RAP anticorps (AA 484-518)

N° du produit ABIN6242410

Cet anticorps anti-IL1RAP est un anticorps Lapin Polyclonal détectant IL1RAP dans WB et IHC (p). Adapté pour Humain et Souris.

Aperçu rapide pour IL1RAP anticorps (AA 484-518) (ABIN6242410)

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1RAP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB57769

Détail du produit anti-IL1RAP anticorps

Épitope: AA 484-518

Homologie: H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 484-518 amino acids of human IL1RAP.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur IL1RAP

Antigène: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Autre désignation: IL1RAP

Sujet: Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Poids moléculaire: 65418

UniProt: Q9NPH3

Pathways: Signalisation NF-kappaB, Growth Factor Binding