MUC4 anticorps (N-Term)

N° du produit ABIN6242467

Cet anticorps anti-MUC4 est un anticorps Lapin Polyclonal détectant MUC4 dans WB. Adapté pour Humain.

Aperçu rapide pour MUC4 anticorps (N-Term) (ABIN6242467)

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUC4 est non-conjugé

Application: Western Blotting (WB)

Clone: RB49957

Détail du produit anti-MUC4 anticorps

Épitope: AA 529-560, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MUC4(Mucin-4 alpha chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 529-560 amino acids from the N-terminal region of human MUC4(Mucin-4 alpha chain).

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur MUC4

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Autre désignation: MUC4(Mucin-4 alpha chain)

Sujet: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Poids moléculaire: 231518

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity