OTUB1 anticorps (AA 185-219)

N° du produit ABIN6242508

L’anticorps anti-OTUB1 Polyclonal Lapin est utilisé pour la détection de OTUB1 dans des échantillons de Humain et Souris. Il a été validé pour WB.

Aperçu rapide pour OTUB1 anticorps (AA 185-219) (ABIN6242508)

Antigène: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUB1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB53068

Détail du produit anti-OTUB1 anticorps

Épitope: AA 185-219

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This OTUB1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 185-219 amino acids from human OTUB1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur OTUB1

Antigène: OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Autre désignation: OTUB1

Sujet: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.

Poids moléculaire: 31284

UniProt: Q96FW1