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PTEN anticorps (N-Term)

PTEN Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB05082 unconjugated
N° du produit ABIN6242545
  • Antigène Voir toutes PTEN Anticorps
    PTEN (Phosphatase and Tensin Homolog (PTEN))
    Épitope
    • 20
    • 19
    • 19
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 69-104, N-Term
    Reactivité
    • 61
    • 23
    • 21
    • 5
    • 4
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 60
    • 1
    Lapin
    Clonalité
    • 59
    • 2
    Polyclonal
    Conjugué
    • 46
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PTEN est non-conjugé
    Application
    • 37
    • 21
    • 21
    • 14
    • 14
    • 13
    • 13
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This PTEN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-104 amino acids from the N-terminal region of human PTEN.
    Clone
    RB05082
    Isotype
    Ig Fraction
  • Indications d'application
    IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Agouni, Mody, Owen, Czopek, Zimmer, Bentires-Alj, Bence, Delibegović: "Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress." dans: The Biochemical journal, Vol. 438, Issue 2, pp. 369-78, (2011) (PubMed).

    Lehman, Waning, Batuello, Cipriano, Kadakia, Mayo: "Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress." dans: The Journal of biological chemistry, Vol. 286, Issue 42, pp. 36631-40, (2011) (PubMed).

  • Antigène
    PTEN (Phosphatase and Tensin Homolog (PTEN))
    Autre désignation
    PTEN (PTEN Produits)
    Synonymes
    anticorps 10q23del, anticorps BZS, anticorps CWS1, anticorps DEC, anticorps GLM2, anticorps MHAM, anticorps MMAC1, anticorps PTEN1, anticorps TEP1, anticorps 2310035O07Rik, anticorps A130070J02Rik, anticorps AI463227, anticorps B430203M17Rik, anticorps Mmac, anticorps PTENP1, anticorps wu:fc52g04, anticorps zgc:73086, anticorps fa11a08, anticorps fb73f10, anticorps fc83f12, anticorps fd16b10, anticorps fk90e11, anticorps pten, anticorps si:bz1g13.4, anticorps wu:fa11a08, anticorps wu:fb73f10, anticorps wu:fc83f12, anticorps wu:fd16b10, anticorps wu:fk90e11, anticorps phosphatase and tensin homolog, anticorps phosphatase and tensin homolog L homeolog, anticorps phosphatase and tensin homolog A, anticorps phosphatase and tensin homolog B, anticorps PTEN, anticorps Pten, anticorps pten.L, anticorps ptena, anticorps ptenb
    Sujet
    PTEN, (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), is a tumor suppressor implicated in a large number of human tumors. The PTEN phosphatase incorporates the catalytic motif (HCXXGXXRS/T) that is a signature of the protein tyrosine phosphatase family. Recombinant human PTEN is a dual phosphatase with ability to dephosphorylate both tyrosine and serine/threonine residues. PTEN functions primarily as a lipid phosphatase to regulate signal transduction pathways, with a primary target identified as phosphatidylinositol 3,4,5 trisphosphate. In addition, PTEN presents weak tyrosine phosphatase activity, which may downregulate signaling pathways involving focal adhesion kinase or Shc. PTEN negatively regulates activation of the serine/threonine kinase Akt/PKB by blocking its phosphorylation, thereby inhibiting the PI 3 kinase Akt signaling pathway, which is important for cell survival. In vivo, the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity. Mutations in PTEN are associated with several common cancers including prostate, brain and breast cancer, and with Cowden's disease, an autosomal dominant disorder conferring susceptibility to benign and malignant tumors. Germline mutations of PTEN are also linked Lhermitte-Duclos disease and Bannayan-Zonana syndrome. Mutations of PTEN occur in 60 to 80 % of prostate cancers. PTEN is also essential for embryonic development.
    Poids moléculaire
    47166
    NCBI Accession
    NP_000305
    UniProt
    P60484
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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