KCTD11 anticorps (AA 21-53)

N° du produit ABIN6242571

L’anticorps anti-KCTD11 Polyclonal produit chez le Lapin a été validé pour WB et IHC (p). Il convient pour la détection de KCTD11 dans des échantillons provenant de Humain et Souris. }

Aperçu rapide pour KCTD11 anticorps (AA 21-53) (ABIN6242571)

Antigène: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCTD11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB54391

Détail du produit anti-KCTD11 anticorps

Épitope: AA 21-53

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000-1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur KCTD11

Antigène: KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))

Autre désignation: KCTD11

Sujet: Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

Poids moléculaire: 25887

UniProt: Q693B1

Pathways: Signalisation Hedgehog