TYRO3 anticorps (C-Term)

N° du produit ABIN6242617

Cet anticorps anti-TYRO3 est un anticorps Lapin Polyclonal détectant TYRO3 dans WB. Adapté pour Rat.

Aperçu rapide pour TYRO3 anticorps (C-Term) (ABIN6242617)

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYRO3 est non-conjugé

Application: Western Blotting (WB)

Clone: RB50580

Détail du produit anti-TYRO3 anticorps

Épitope: AA 854-878, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TYRO3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 854-878 amino acids from the C-terminal region of human TYRO3.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur TYRO3

Antigène: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Autre désignation: TYRO3

Sujet: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Poids moléculaire: 96905

UniProt: Q06418

Pathways: Signalisation RTK