Nischarin anticorps (AA 5-38)

N° du produit ABIN6242733

Détail du produit anti-Nischarin anticorps

Antigène: Nischarin (NISCH)

Épitope: AA 5-38

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nischarin est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NISCH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 5-38 amino acids from human NISCH.

Clone: RB55910

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur Nischarin

Antigène: Nischarin (NISCH)

Autre désignation: NISCH (NISCH Produits)

Synonymes: anticorps NISCH, anticorps IRAS, anticorps 1200007D05Rik, anticorps 3202002H23Rik, anticorps AW494485, anticorps I-1, anticorps IR1, anticorps hIRAS, anticorps nischarin, anticorps nischarin S homeolog, anticorps NISCH, anticorps Cyan7822_6841, anticorps nisch.S, anticorps nisch, anticorps Nisch

Sujet: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

Poids moléculaire: 166629

UniProt: Q9Y2I1