Nischarin anticorps (AA 1100-1150)

N° du produit ABIN7451170

Détail du produit anti-Nischarin anticorps

Antigène: Nischarin (NISCH)

Épitope: AA 1100-1150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nischarin est non-conjugé

Application: Immunoprecipitation (IP)

Fonction: Rabbit anti-NISCH Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 1100 and 1150

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451170 has not performed satisfactorily when used for WB of NISCH in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of NISCH.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Nischarin

Antigène: Nischarin (NISCH)

Autre désignation: NISCH (NISCH Produits)

Synonymes: anticorps NISCH, anticorps IRAS, anticorps 1200007D05Rik, anticorps 3202002H23Rik, anticorps AW494485, anticorps I-1, anticorps IR1, anticorps hIRAS, anticorps nischarin, anticorps nischarin S homeolog, anticorps NISCH, anticorps Cyan7822_6841, anticorps nisch.S, anticorps nisch, anticorps Nisch

Sujet: Background: Nischarin (NISCH) is a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of NISCH was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation[taken from NCBI Entrez Gene (Gene ID: 11188)].

ID gène: 11188

UniProt: Q9Y2I1