CYLD anticorps (AA 305-582)

N° du produit ABIN6242844

L’anticorps Souris Monoclonal anti-CYLD a été validé pour WB et FACS. Il convient pour détecter CYLD dans des échantillons de Humain.

Aperçu rapide pour CYLD anticorps (AA 305-582) (ABIN6242844)

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CYLD est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 1667CT857-3-6-1

Détail du produit anti-CYLD anticorps

Épitope: AA 305-582

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD.

Isotype: IgG2a kappa

Information d'application

Indications d'application: WB: 1:4000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur CYLD

Antigène: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Autre désignation: CYLD

Sujet: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917689" target="_blank">12917689, PubMed:< a href="http://www.uniprot.org/citations/12917691" target="_blank">12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917690" target="_blank">12917690). Negative regulator of Wnt signaling (PubMed:< a href="http://www.uniprot.org/citations/20227366" target="_blank">20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:< a href="http://www.uniprot.org/citations/18222923" target="_blank">18222923, PubMed:< a href="http://www.uniprot.org/citations/20194890" target="_blank">20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:< a href="http://www.uniprot.org/citations/17495026" target="_blank">17495026, PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/18636086" target="_blank">18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity).

Poids moléculaire: 107316

UniProt: Q9NQC7

Pathways: Apoptose, Activation of Innate immune Response