EHMT2 anticorps (AA 589-623)

N° du produit ABIN6243048

L’anticorps Lapin Polyclonal anti-EHMT2 a été validé pour WB. Il convient pour détecter EHMT2 dans des échantillons de Souris.

Aperçu rapide pour EHMT2 anticorps (AA 589-623) (ABIN6243048)

Antigène: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EHMT2 est non-conjugé

Application: Western Blotting (WB)

Clone: RB52371

Détail du produit anti-EHMT2 anticorps

Épitope: AA 589-623

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Ehmt2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 589-623 amino acids from the Central region of Mouse Ehmt2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur EHMT2

Antigène: EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Autre désignation: Ehmt2

Sujet: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

Poids moléculaire: 138039

UniProt: Q9Z148