RGS19 anticorps (N-Term)

N° du produit ABIN6243052

Cité dans 2 publications. Cet anticorps anti-RGS19 Polyclonal Lapin (Clone RB7576) (ABIN6243052) détecte spécifiquement RGS19 dans WB et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RGS19 anticorps (N-Term) (ABIN6243052)

Antigène: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RGS19 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7576

Détail du produit anti-RGS19 anticorps

Épitope: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RGS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-term of human RGS19.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-RGS19 (ABIN6243052)

Li, Wang, Chen, Lu, Wang, Duan, Tian, Wang, You, Zou, Cheng, Zhu, Wan, Xi, Jiang, Han, Cao, Birnbaumer, Chu, Yang: "Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 15, pp. 4731-6, (2015) (PubMed).

Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." dans: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, (2011) (PubMed).

Détails sur RGS19

Antigène: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Autre désignation: RGS19

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.

Poids moléculaire: 24636

NCBI Accession: NP_001034556, NP_005864

UniProt: P49795

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling