CHST4 anticorps (C-Term)

N° du produit ABIN6243109

Cet anticorps anti-CHST4 est un anticorps Lapin Polyclonal détectant CHST4 dans WB. Adapté pour Humain.

Aperçu rapide pour CHST4 anticorps (C-Term) (ABIN6243109)

Antigène: CHST4 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4 (CHST4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHST4 est non-conjugé

Application: Western Blotting (WB)

Clone: RB52322

Détail du produit anti-CHST4 anticorps

Épitope: AA 357-390, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CHST4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 357-390 amino acids from the C-terminal region of human CHST4.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur CHST4

Antigène: CHST4 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4 (CHST4))

Autre désignation: CHST4

Sujet: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2- branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1- 3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.

Poids moléculaire: 45134

UniProt: Q8NCG5