FZR1 anticorps (AA 1-496)

N° du produit ABIN6243204

L’anticorps Souris Monoclonal anti-FZR1 a été validé pour WB. Il convient pour détecter FZR1 dans des échantillons de Humain.

Aperçu rapide pour FZR1 anticorps (AA 1-496) (ABIN6243204)

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FZR1 est non-conjugé

Application: Western Blotting (WB)

Clone: 1621CT637-76-67

Détail du produit anti-FZR1 anticorps

Épitope: AA 1-496

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur FZR1

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Autre désignation: FZR

Sujet: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Poids moléculaire: 55179

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA