IFITM3 anticorps (N-Term)

N° du produit ABIN6243232

Cet anticorps anti-IFITM3 est un anticorps Souris Monoclonal détectant IFITM3 dans WB. Adapté pour Humain.

Aperçu rapide pour IFITM3 anticorps (N-Term) (ABIN6243232)

Antigène: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IFITM3 est non-conjugé

Application: Western Blotting (WB)

Clone: 1082CT14-1-3-1

Détail du produit anti-IFITM3 anticorps

Épitope: AA 1-133, N-Term

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This IFITM3 antibody is generated from a mouse immunized with a recombinant protein KLH conjugated synthetic peptide between 1-133 amino acids from the N-terminal region of human IFITM3.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:4000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur IFITM3

Antigène: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Autre désignation: IFITM3

Sujet: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Poids moléculaire: 14632

UniProt: Q01628