MLL2 anticorps (C-Term)

N° du produit ABIN6243263

Détail du produit anti-MLL2 anticorps

Antigène: MLL2 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2))

Épitope: AA 4980-5009, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MLL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4980-5009 amino acids from the C-terminal region of human MLL2.

Clone: RB1919-1920

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:80000. WB: 1:27000. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-MLL2 (ABIN6243263)

Kim, Sharma, Dhar, Lee, Gu, Chan, Lin, Lee: "UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells." dans: Cancer research, Vol. 74, Issue 6, pp. 1705-17, (2014) (PubMed).

Bhan, Hussain, Ansari, Bobzean, Perrotti, Mandal: "Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo." dans: The Journal of steroid biochemistry and molecular biology, Vol. 141, pp. 160-70, (2014) (PubMed).

Dhar, Lee, Kan, Voigt, Ma, Shi, Reinberg, Lee: "Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4." dans: Genes & development, Vol. 26, Issue 24, pp. 2749-62, (2012) (PubMed).

Détails sur MLL2

Antigène: MLL2 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2))

Autre désignation: MLL2 (MLL2 Produits)

Synonymes: anticorps AAD10, anticorps ALR, anticorps CAGL114, anticorps KABUK1, anticorps KMS, anticorps MLL2, anticorps MLL4, anticorps TNRC21, anticorps HRX2, anticorps MLL1B, anticorps TRX2, anticorps WBP7, anticorps BC032281, anticorps BC058659, anticorps C430014K11Rik, anticorps KMT2B, anticorps Mll2, anticorps Mll4, anticorps lysine methyltransferase 2D, anticorps lysine methyltransferase 2B, anticorps lysine (K)-specific methyltransferase 2D, anticorps myeloid/lymphoid or mixed-lineage leukemia 2, anticorps KMT2D, anticorps KMT2B, anticorps Kmt2d, anticorps MLL2

Sujet: The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL2. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. The gene for MLL2 encodes a 5,262-amino acid protein containing a SET domain, 5 PHD fingers, potential zinc fingers, and a long run of glutamines interrupted by hydrophobic residues (mostly leucine). They also detected an alternatively spliced form encoding 4,957 amino acids and lacking an N-terminal zinc finger and PHD finger. By analysis of rodent/human hybrid cells and analysis of the Genebridge radiation hybrid panel, they mapped the gene to the 12p13.1-qter region. The 12q12-q13 region is involved in duplications and translocations associated with cancer. By database searching, Karlin et al. (2002) identified 192 human protein sequences that have multiple amino acid runs, many of which are associated with disease, including cancer. Karlin et al. (2002) found that a key aspect of 82 of these protein sequences is their role in transcription, translation, and developmental regulation. MLL2 is a striking example of proteins with multiple amino acid runs, with 22 glutamine runsGenes encoding a significant number of long amino acid runs are potentially associated with diseases, such as cancer.

Poids moléculaire: 593389

NCBI Accession: NP_003473

UniProt: O14686

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, L'effet Warburg