TRRAP anticorps (C-Term)

N° du produit ABIN6243321

L’anticorps Lapin Polyclonal anti-TRRAP a été validé pour WB et IF. Il convient pour détecter TRRAP dans des échantillons de Humain.

Aperçu rapide pour TRRAP anticorps (C-Term) (ABIN6243321)

Antigène: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRRAP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB51386

Détail du produit anti-TRRAP anticorps

Épitope: AA 3015-3049, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TRRAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 3015-3049 amino acids from the C-terminal region of human TRRAP.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur TRRAP

Antigène: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Autre désignation: TRRAP

Sujet: Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Poids moléculaire: 437600

UniProt: Q9Y4A5